Case 212

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Chapter 212

1 Abstract Since the industrial revolution, standardization has become a hybrid of technical design and political processes with major impact on markets, social welfare and economic activity. Standards are increasingly developed outside government regulatory venues in consortia and other forms of voluntary consensus bodies involving collaboration among private sector competitors, suppliers, cus...

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Navitoclax (ABT-263), a Bcl-2 family inhibitor and ABT-199, a Bcl-2 selective inhibitor, are high molecular weight, high logP molecules that show low solubility in aqueous media. While these properties are associated with low oral bioavailability (F), both navitoclax and ABT-199 showed moderate F in preclinical species. The objective of the described study was to determine if lymphatic transpor...

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ion at the b-C. Relative yields are changed as much as a factor of 7.0 at 200 K, a factor of 5.0 at 298 K, and a factor of 3.7 in the other direction at 2400 K. The strong dependence of the product ratios on the multi-structural anharmonicity factors shows that such factors play an important role in controlling branching ratios in reaction mechanism networks.

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Estrogen is a hormone critical in the development, normal physiology and pathophysiology1 of numerous human tissues2. The effects of estrogen have traditionally been solely ascribed to estrogen receptor a (ERa) and more recently ERb, members of the soluble, nuclear ligand–activated family of transcription factors3. We have recently shown that the seventransmembrane G protein–coupled receptor GP...

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ژورنال

عنوان ژورنال: Radiology

سال: 2014

ISSN: 0033-8419,1527-1315

DOI: 10.1148/radiol.14131354